Dissolution behavior of indometacin polymorphs.
نویسندگان
چکیده
منابع مشابه
Kinetics of amorphous silica dissolution and the paradox of the silica polymorphs.
The mechanisms by which amorphous silica dissolves have proven elusive because noncrystalline materials lack the structural order that allows them to be studied by the classical terrace, ledge, kink-based models applied to crystals. This would seem to imply amorphous phases have surfaces that are disordered at an atomic scale so that the transfer of SiO(4) tetrahedra to solution always leaves t...
متن کاملIn Vitro Dissolution of Insulin Crystal Polymorphs at Model Conditions Relevant to In Vivo Environment
In vivo dissolution of crystalline insulin formulations is an important step for insulin absorption in the subcutaneous therapy of diabetes, which is the most widespread. Here, data on the in vitro dissolution of three different crystalline forms of commercial porcine insulin are reported. The aim of this study was to create a model framework of in vivo dissolution of insulin crystalline formul...
متن کاملDissolution behavior of fluoroalcohol substituted polystyrenes
α-Fluoroalcohols have been proposed as transparent, base-soluble functional groups for use in the design of new 157 nm photoresist polymers. The two most common and easily prepared fluoroisopropanol groups are bis-trifluoromethyl carbinols (hexafluoroalcohol) and methyl-trifluoromethyl carbinols (trifluoroalcohol). This paper describes studies designed to assess the suitability of both of these...
متن کاملDiscriminatory Dissolution Test for Tablets Containing a- and b-Thalidomide Polymorphs
Over the years, thalidomide has been prescribed for an increasing number of diseases, including multiple myeloma and erythema nodosum leprosum. In Brazil and other countries, thalidomide is available in tablets, and there is no official dissolution testing available for this dosage form. Considering this, a dissolution method was developed and validated for tablets containing 100 mg of each pol...
متن کاملApplication of Taguchi Method to Investigate the Effects of Process Factors on the Production of Industrial Piroxicam Polymorphs and Optimization of Dissolution Rate of Powder
Piroxicam has two different crystalline forms (known as needle and cubic forms), that they are different in physicochemical properties such as biological solubility. In the current research, using Taguchi experimental design approach the influences of five operating variables on formation of the piroxicam polymorph shapes in recrystallization were studied. The variables include type of solvent,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Society of Powder Technology, Japan
سال: 1990
ISSN: 0386-6157,1883-7239
DOI: 10.4164/sptj.27.11